The enigma of cobalamin (vitamin B12) biosynthesis in Porphyromonas gingivalis: identification and characterisation of a functional corrin pathway
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The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway.
The ability of Porphyromonas gingivalis to biosynthesize tetrapyrroles de novo has been investigated. Extracts of the bacterium do not possess activity for 5- aminolevulinic-acid dehydratase or porphobilinogen deaminase, two key enzymes involved in the synthesis of uroporphyrinogen III. Similarly, it was not possible to detect any genetic evidence for these early enzymes with the use of degener...
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Vitamin B12 (VB12) is an essential water-soluble vitamin that also known as Cobalamin [1]. It is composed of a corrin ring consisting of four pyrrole units and a cobalt ion at the center of the ring [2]. 1VB12 is manufactured by microorganisms present in the liver of animals bound to protein. The average B12 content of liver tissue is approximately 1.0 microgram/g of tissue in healthy adults [3...
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